Naive CD4 T cells inhibit CD28-costimulated R5 HIV replication in memory CD4 T cells
نویسندگان
چکیده
منابع مشابه
Naive CD4 T cells inhibit CD28-costimulated R5 HIV replication in memory CD4 T cells.
Stimulation with antibodies to CD3 and CD28 coimmobilized on beads can be used to significantly expand T cells ex vivo. With CD4 T cells from HIV-infected patients, this expansion usually is accompanied by complete suppression of viral replication, presumed to be caused by down-regulation of the viral coreceptor CCR5 and up-regulation of CCR5 ligands. Here we show that this suppression occurs i...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2001
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.211205098